top of page

Disclaimer: All products are for laboratory research only and not for human or animal use or consumption. For in-vitro research by qualified professionals only

5-amino-1mq

5-amino-1mq

$20.99Price
Quantity
5mg
10mg
Quantity

Purchase 5-Amino-1MQ Research Compound

5-Amino-1MQ (5-Amino-1-methylquinolinium) is a small molecule nicotinamide N-methyltransferase (NNMT) inhibitor extensively studied in metabolic biology and obesity research for its role as a selective modulator of cellular methylation capacity and NAD⁺ metabolism. This novel research compound serves as a critical tool for investigating adipogenesis regulation, energy expenditure pathways, and epigenetic methylation dynamics in preclinical models.

5-Amino-1MQ Identity & Structural Overview

5-Amino-1MQ is a cationic quaternary amine compound derived from the quinolinium scaffold, structurally designed to competitively inhibit NNMT by occupying the nicotinamide binding pocket of the enzyme. Its compact molecular architecture enables favorable cellular membrane permeability and tissue distribution in preclinical pharmacokinetic studies. The amino group at the 5-position and quaternary nitrogen at position 1 are critical structural determinants for selective NNMT binding affinity and inhibitory activity in biochemical assay systems.

Mechanism of Action

Preclinical research demonstrates that 5-Amino-1MQ selectively inhibits NNMT, an enzyme responsible for methylating nicotinamide using S-adenosylmethionine (SAM) as the methyl donor. By blocking NNMT activity, studies have documented downstream elevation of intracellular NAD⁺ and SAM concentrations, activation of SIRT1-mediated metabolic signaling, suppression of adipocyte differentiation, and enhancement of cellular energy expenditure through upregulation of thermogenic gene expression in isolated adipose tissue preparations and intact animal models.

Key Research Findings

Foundational research by Neelakantan et al. published in Nature Communications demonstrated that selective NNMT inhibition with a structural analog reduced body weight, decreased white adipose tissue mass, and improved metabolic parameters in diet-induced obesity mouse models without observable cytotoxicity. Subsequent preclinical studies have further characterized 5-Amino-1MQ's capacity to modulate the SAM-to-SAH ratio, influence epigenetic methylation patterns, and enhance skeletal muscle energy metabolism in isolated tissue and in vivo animal preparations.

Product Specifications

  • Form: Lyophilized powder (synthetic, high-purity)

  • Chemical Name: 5-Amino-1-methylquinolinium

  • Molecular Formula: C₁₀H₁₁N₂⁺ (as cationic salt)

  • Molecular Weight: 159.2 Da (free base)

  • Quantity: Single-vial format

  • Storage: −20°C; protect from light; unopened shelf life of 24 months

  • Reconstitution: Sterile water or dimethyl sulfoxide (DMSO) per experimental protocol

  • Purity: >95% (HPLC verified); endotoxin <1 EU/μg

Research Use Only

For preclinical research purposes only. Not intended for human or veterinary use. All handling must adhere to institutional biosafety committee guidelines.

    bottom of page