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Disclaimer: All products are for laboratory research only and not for human or animal use or consumption. For in-vitro research by qualified professionals only

5 AMINO 1MQ 50mg

5 AMINO 1MQ 50mg

$50.00Price
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Purchase 5-Amino-1MQ 50mg for Laboratory Research

This molecule is a potent, cell-permeable inhibitor of nicotinamide N-methyltransferase (NNMT), widely examined in early-stage metabolic research. As a quinolinium-based compound, it readily enters cells, making it useful for studying intracellular NAD+ regulation and methylation pathways without the need for transfection methods or specialized delivery systems.

Biochemical Function of 5-Amino-1MQ

NNMT is responsible for transferring a methyl group from S-adenosyl methionine (SAM) to nicotinamide, producing N1-methylnicotinamide. This compound interferes with that enzymatic process in vitro, allowing researchers to explore its role in cellular metabolism and epigenetic regulation. Enzyme inhibition assays have demonstrated strong activity, with IC50 values in the nanomolar range.

Scientific Background

Findings reported in Cell Metabolism (2020) highlighted the involvement of NNMT in metabolic shifts within cultured cancer cells, including changes in glucose metabolism and NAD+/NADH balance following inhibition. Further work published in Science Translational Medicine (2022) investigated the compound’s selectivity and interaction with NNMT through biochemical testing and structural analysis using X-ray crystallography.

Formulation and Storage

Provided as a 5mg lyophilized powder. For optimal stability, store at -20°C in a dry, sealed environment, where it remains stable for over two years. The compound dissolves in DMSO and standard aqueous buffers, making it suitable for cell culture applications. Typical in vitro working concentrations range from 1 to 50 μM.

Quality and Specifications

Purity is ≥98% as verified by HPLC and mass spectrometry. The product is tested for endotoxins and is appropriate for use in sensitive cell-based assays. It is also compatible with high-throughput and automated screening systems.

Research Use Statement

This material is strictly intended for laboratory research and preclinical studies. It is not approved for human or clinical use, nor for in vivo applications. Proper handling, storage, and disposal should follow all applicable institutional and safety guidelines.

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