AHK-CU
Purchase AHK-Cu Research Peptide
AHK-Cu (Ala-His-Lys copper complex) is a synthetic tripeptide-copper complex widely studied in dermatological and wound healing research for its role in tissue repair, collagen synthesis, and cellular regeneration. This bioactive peptide-copper complex serves as an essential research tool for investigating skin biology, angiogenesis, and extracellular matrix remodeling in preclinical models.
AHK-Cu Identity & Structural Overview
AHK-Cu is a tripeptide composed of Alanine-Histidine-Lysine coordinated with a copper (II) ion. The histidine residue serves as the primary copper-chelating site, forming a stable square-planar coordination complex. This copper-binding configuration is critical for its biological activity in cellular assays and tissue preparation models.
Mechanism of Action
Preclinical research demonstrates that AHK-Cu promotes fibroblast proliferation, upregulates collagen and glycosaminoglycan synthesis, and stimulates vascular endothelial growth factor (VEGF) expression. Studies have documented its role in activating tissue remodeling pathways, enhancing wound closure rates, and modulating metalloproteinase activity in both in vitro cell cultures and in vivo animal models.
Key Research Findings
Foundational studies by Pickart et al. established AHK-Cu as a potent modulator of tissue repair signaling, demonstrating its capacity to stimulate collagen production and accelerate wound healing in preclinical preparations. Subsequent research has further documented its antioxidant properties and ability to support hair follicle proliferation in isolated tissue models.
Product Specifications
Form: Lyophilized powder (synthetic, high-purity)
Composition: Ala-His-Lys tripeptide complexed with copper (II)
Molecular Weight: 403.9 Da
Quantity: Single-vial format
Storage: −20°C; unopened shelf life of 24 months
Reconstitution: Sterile water or bacteriostatic saline
Purity: >95% (HPLC verified); endotoxin <1 EU/μg
Research Use Only
For preclinical research purposes only. Not intended for human or veterinary use. All handling must adhere to institutional biosafety committee guidelines.
