Vesugen

Vesugen for Laboratory Research

Vesugen is a synthetic tripeptide (Lys-Glu-Asp) developed as a bioregulatory peptide with specific affinity for vascular tissue. It belongs to a class of short-chain peptides studied for their ability to interact with nuclear chromatin and influence gene expression patterns in a tissue-selective manner. It has been used in preclinical research focused on vascular endothelial function and blood vessel biology.

Biochemical Function of Vesugen

As a cytogen-class peptide, Vesugen is thought to interact directly with DNA and histone proteins, modulating the transcriptional activity of genes associated with endothelial cell maintenance and vascular homeostasis. In vitro studies have examined its influence on cell proliferation, protein synthesis, and markers of cellular aging in endothelial cell lines, positioning it as a useful research tool for studying vascular biology at the molecular level.

Scientific Background

Research originating from the St. Petersburg Institute of Bioregulation and Gerontology has characterized the tissue-specific binding properties of Vesugen and related peptide bioregulators. Studies have investigated its effects on endothelial cell cultures, including changes in proliferative capacity and gene expression profiles relevant to vascular function. This body of work has contributed to broader investigation into short peptide interactions with chromatin and their downstream transcriptional effects.

Formulation and Storage

Provided as a lyophilized powder. For optimal stability, store at -20°C in a dry, sealed environment. Once reconstituted, aliquot into single-use volumes and avoid repeated freeze-thaw cycles to maintain peptide integrity. Vesugen is typically reconstituted in sterile water or phosphate-buffered saline and is compatible with standard cell culture systems.

Quality and Specifications

Purity is ≥98% as verified by HPLC and mass spectrometry. Each lot is tested to confirm sequence identity and is appropriate for use in cell-based assays and biochemical studies. Compatible with standard laboratory workflows including multi-well plate formats and automated screening systems.

Research Use Statement

This material is strictly intended for laboratory research and preclinical studies. It is not approved for human or clinical use, nor for in vivo applications. Proper handling, storage, and disposal should follow all applicable institutional and safety guidelines.