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Disclaimer: All products are for laboratory research only and not for human or animal use or consumption. For in-vitro research by qualified professionals only

Cardiogen

Cardiogen

$49.99Price
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Purchase Cardiogen Research Peptide

Cardiogen is a synthetic tetrapeptide extensively studied in cardiovascular biology and aging research for its role as a selective modulator of cardiac gene expression and myocardial tissue homeostasis. This bioregulatory peptide serves as a critical research tool for investigating cardiomyocyte function, cardiac tissue repair mechanisms, and age-related myocardial deterioration in preclinical models.

Cardiogen Identity & Structural Overview

Cardiogen (Ala-Glu-Asp-Gly) is a four-amino acid bioregulatory peptide belonging to the class of short peptide bioregulators originally developed through cytomax peptide isolation research. Its compact tetrapeptide structure enables favorable cellular membrane interaction and nuclear translocation properties documented in preclinical pharmacological studies. The specific amino acid sequence is recognized as a tissue-selective signal peptide with preferential affinity for cardiac chromatin binding sites in isolated nuclear preparation assays.

Mechanism of Action

Preclinical research demonstrates that Cardiogen exerts its cardioprotective effects through direct interaction with nuclear chromatin, modulating the transcriptional activity of genes governing cardiomyocyte proliferation, differentiation, and survival. Studies have documented its capacity to stimulate cardiac progenitor cell activity, enhance cardiomyocyte protein synthesis, normalize age-related disruptions in myocardial gene expression profiles, and attenuate oxidative stress-induced apoptotic signaling in isolated cardiac tissue preparations. Additional research has characterized its role in supporting intercellular junction integrity and myofibril organization in aged cardiac tissue models.

Key Research Findings

Foundational research by Khavinson et al. established Cardiogen as a cardioselective bioregulatory peptide through chromatin binding studies, demonstrating preferential affinity for cardiac tissue nuclear fractions compared to non-cardiac tissue preparations. Subsequent preclinical investigations documented Cardiogen-mediated restoration of cardiomyocyte functional parameters in aged animal models, with observed improvements in myocardial contractility markers, reduction in fibrotic remodeling indices, and normalization of cardiac gene expression patterns in senescent tissue preparations compared to untreated age-matched controls.

Product Specifications

  • Form: Lyophilized powder (synthetic, high-purity)

  • Sequence: Ala-Glu-Asp-Gly

  • Amino Acid Composition: 4 amino acids

  • Molecular Weight: 374.3 Da

  • Quantity: Single-vial format

  • Storage: −20°C; unopened shelf life of 24 months

  • Reconstitution: Sterile water or bacteriostatic saline

  • Purity: >95% (HPLC verified); endotoxin <1 EU/μg

Research Use Only

For preclinical research purposes only. Not intended for human or veterinary use. All handling must adhere to institutional biosafety committee guidelines.

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