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Disclaimer: All products are for laboratory research only and not for human or animal use or consumption. For in-vitro research by qualified professionals only

Cortagen

Cortagen

$49.99Price
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Purchase Cortagen Research Peptide

Cortagen is a synthetic tetrapeptide extensively studied in neurobiology and aging research for its role as a selective modulator of cortical neuronal gene expression and central nervous system tissue homeostasis. This bioregulatory peptide serves as a critical research tool for investigating neuronal survival mechanisms, age-related cognitive decline pathways, and cerebrocortical tissue repair in preclinical models.

Cortagen Identity & Structural Overview

Cortagen (Ala-Glu-Asp-Pro) is a four-amino acid bioregulatory peptide belonging to the class of short peptide bioregulators developed through cytomax peptide isolation methodology. Its compact tetrapeptide architecture enables favorable nuclear translocation properties and selective chromatin binding affinity documented in preclinical pharmacological studies. The proline residue at the C-terminal position confers structural rigidity and resistance to nonspecific peptidase degradation, enhancing stability in biological assay systems compared to flexible linear tetrapeptides.

Mechanism of Action

Preclinical research demonstrates that Cortagen exerts its neuroprotective effects through direct interaction with cortical neuronal chromatin, selectively modulating transcriptional activity of genes governing neuronal differentiation, synaptic plasticity, and cellular survival. Studies have documented its capacity to stimulate cortical neuron proliferation and differentiation in primary culture preparations, enhance neurotrophic factor expression, attenuate glutamate-induced excitotoxic apoptotic signaling, and normalize age-related disruptions in cortical gene expression profiles in isolated neural tissue preparations and intact animal models.

Key Research Findings

Foundational research by Khavinson et al. established Cortagen as a cerebroselective bioregulatory peptide through nuclear chromatin binding studies, demonstrating preferential affinity for cortical neuronal nuclear fractions compared to non-neural tissue preparations. Subsequent preclinical investigations documented Cortagen-mediated improvements in neuronal survival parameters following ischemic and oxidative insult models, with observed enhancement of cortical tissue regenerative capacity, restoration of synaptic density markers, and normalization of neurotrophic signaling indices in aged and lesioned animal model systems compared to untreated controls.

Product Specifications

  • Form: Lyophilized powder (synthetic, high-purity)

  • Sequence: Ala-Glu-Asp-Pro

  • Amino Acid Composition: 4 amino acids

  • Molecular Weight: 400.4 Da

  • Quantity: Single-vial format

  • Storage: −20°C; unopened shelf life of 24 months

  • Reconstitution: Sterile water or bacteriostatic saline

  • Purity: >95% (HPLC verified); endotoxin <1 EU/μg

Research Use Only

For preclinical research purposes only. Not intended for human or veterinary use. All handling must adhere to institutional biosafety committee guidelines.

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