Follistatin 344 1mg

Follistatin 344 1mg Research Peptide

Follistatin 344 is an endogenously occurring glycoprotein recognized in preclinical research as a myostatin antagonist. This 344-amino-acid isoform is examined in preclinical models for its capacity to influence growth factor signaling, primarily through its ability to bind and sequester myostatin and activin ligands in non-human research settings.

Follistatin 344 Research Background

The core mechanism by which Follistatin 344 operates involves competitive inhibition of TGF-β (transforming growth factor-beta) superfamily proteins. In both cell culture systems and animal model studies, Follistatin 344 exhibits strong binding affinity for myostatin and activins, effectively preventing these ligands from engaging their target receptors. Research by Lee et al. (2005) established that Follistatin expression levels correlate with enlarged muscle fiber diameter in preclinical models, attributed to the suppression of myostatin-driven signaling.

Follistatin 344 Mechanism of Action

Studies employing transgenic and knockout animal models have demonstrated that Follistatin 344 exerts influence over muscle growth and differentiation signaling networks. In vitro evidence points to the peptide functioning as an ActRIIB receptor antagonist, interrupting downstream phosphorylation of the SMAD2/3 cascade. McCroskery et al. (2003) reported significant gains in muscle mass in experimental animals with elevated Follistatin expression, helping to establish the mechanistic link between Follistatin activity and skeletal muscle development.

Follistatin 344 1mg — Product Specifications & Storage

Follistatin 344 is supplied as pharmaceutical-grade lyophilized powder in 1mg vials. For reconstitution, sterile water or bacteriostatic saline is recommended; once reconstituted, solutions remain stable for up to 48 hours when stored at 4°C. Unreconstituted powder should be kept at −20°C for long-term preservation of molecular integrity under controlled laboratory conditions.

Research Use Only

This product is designated strictly for in vitro laboratory research. It is not intended for human administration, clinical trials, or any therapeutic use. All applications must conform to applicable institutional protocols and regulatory frameworks governing peptide-based research.