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Disclaimer: All products are for laboratory research only and not for human or animal use or consumption. For in-vitro research by qualified professionals only

GLP-1 (SMA)

GLP-1 (SMA)

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Product Overview & SpecificationsGLP-1 Receptor Agonist Analog (SMA) is an engineered 31-amino-acid peptide developed to provide extended activity through structural modifications that improve stability against enzymatic breakdown. It functions as a selective GLP-1 receptor ligand, making it useful in preclinical research focused on incretin signaling and metabolic regulation in controlled laboratory environments.

Mechanism of ActionThe GLP-1 receptor is part of the secretin family of G-protein-coupled receptors and is found in various metabolic and neurological tissues. Modifications in the SMA version enhance stability while maintaining receptor specificity and activity. In laboratory models, GLP-1 (SMA) activates Gs signaling pathways, increasing intracellular cAMP levels and influencing downstream gene expression. Preclinical studies show effects on insulin signaling, glucagon regulation, and gastrointestinal function through GLP-1 receptor activity.

Research BackgroundStudies such as Fineman et al. (2002) have examined the pharmacological behavior of extended-activity GLP-1 analogs, highlighting the relationship between signaling duration and metabolic responses. Research by Nauck et al. (2001) further explores GLP-1 receptor involvement in nutrient processing and glucose regulation in experimental models. Additional findings suggest central nervous system activity, including potential effects on appetite-related signaling pathways.

Product Details & Storage

  • Form: Lyophilized powder

  • Storage: Store at 2–8°C in a sealed, light-protected environment

  • Reconstitution: Sterile water or bacteriostatic saline recommended

  • Stability: Reconstituted solution remains stable for up to 48 hours under refrigeration

  • Proper handling is important to maintain peptide integrity and prevent degradation

Disclaimer:

For research use only. Not intended for human consumption, medical use, or therapeutic applications. All use must comply with institutional guidelines and applicable laboratory regulations.

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