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Disclaimer: All products are for laboratory research only and not for human or animal use or consumption. For in-vitro research by qualified professionals only

Hexarelin Acetate

Hexarelin Acetate

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Purchase Hexarelin Acetate Research Peptide

Hexarelin Acetate is a synthetic hexapeptide and growth hormone secretagogue extensively studied in neuroendocrinology and metabolic research for its role as a potent activator of the growth hormone secretagogue receptor (GHS-R). This structurally stable peptide serves as a valuable research tool for investigating growth hormone release mechanisms, cardiovascular signaling, and metabolic regulation in preclinical models.

Hexarelin Acetate Identity & Structural Overview

Hexarelin Acetate (His-D-2-MeTrp-Ala-Trp-D-Phe-Lys-NH₂ acetate salt) is a six-amino acid synthetic peptide derived from met-enkephalin. Its structure incorporates D-amino acid substitutions that confer enhanced enzymatic stability compared to endogenous peptides, making it a reliable ligand for receptor binding studies and in vitro biochemical assays.

Mechanism of Action

Preclinical research demonstrates that Hexarelin Acetate binds with high affinity to the GHS-R1a receptor in the pituitary and hypothalamus, stimulating growth hormone release through calcium mobilization and phospholipase C activation. Studies have additionally documented direct cardiac receptor binding activity, with documented effects on ventricular function and cardioprotective signaling pathways independent of growth hormone release in isolated tissue preparations and animal models.

Key Research Findings

Early work by Ghigo et al. established Hexarelin as one of the most potent synthetic growth hormone secretagogues identified, demonstrating superior GH-releasing activity compared to GHRH in preclinical and early observational studies. Subsequent research by Muccioli et al. documented direct myocardial binding sites for Hexarelin, identifying cardiovascular receptor activity and cardioprotective effects in isolated heart preparations and ischemia models.

Product Specifications

  • Form: Lyophilized powder (synthetic, high-purity)

  • Sequence: His-D-2-MeTrp-Ala-Trp-D-Phe-Lys-NH₂ acetate salt

  • Molecular Weight: 887.0 Da

  • Quantity: Single-vial format

  • Storage: −20°C; unopened shelf life of 24 months

  • Reconstitution: Sterile water or bacteriostatic saline

  • Purity: >95% (HPLC verified); endotoxin <1 EU/μg

Research Use Only

For preclinical research purposes only. Not intended for human or veterinary use. All handling must adhere to institutional biosafety committee guidelines.

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