AICAR 10mg capsules (Quantity 100)

Order AICAR 10mg for Laboratory Research

AICAR (5-aminoimidazole-4-carboxamide ribonucleoside) is a synthetic nucleoside analog commonly utilized in experimental settings as an activator of AMP-activated protein kinase (AMPK). In controlled research environments, it serves as a tool for studying cellular energy regulation and metabolic stress pathways without requiring genetic modification techniques.

Biochemical Activity and Function

Within cells, AICAR is converted by adenosine kinase into ZMP, a compound that closely resembles AMP. This metabolite interacts with AMPK, triggering its activation through allosteric mechanisms. Laboratory studies across various cell types—including liver, muscle, and fat cells—have demonstrated changes in glucose transport, mitochondrial activity, and lipid metabolism following treatment, supporting its role in cellular energy signaling research.

Overview of Research Findings

Early investigations published in the American Journal of Physiology (2003) identified AICAR’s ability to activate AMPK in isolated tissue models, observing downstream phosphorylation of key metabolic enzymes. Later studies in journals such as Diabetes (2007, 2009) reported enhanced fatty acid utilization and reductions in intracellular lipid accumulation in cultured adipocytes. Additional work in Cell Metabolism (2012) further validated its effects across multiple experimental systems.

Common Research Applications

AICAR is frequently incorporated into studies examining mitochondrial efficiency, metabolic adaptability, and cellular stress responses. It is also used to explore signaling pathways related to AMPK activation, NAD+ balance, and sirtuin function in vitro. Typical experimental concentrations range from approximately 0.5 to 2 mM, depending on study design.

Product Information – AICAR

Provided as a lyophilized powder (10mg per unit). Recommended storage is at -20°C in a dry, sealed environment. Purity is typically ≥98% as verified by HPLC analysis. For experimental use, it can be reconstituted in sterile water or phosphate-buffered saline to create concentrated stock solutions.

Research Use Statement

This material is supplied strictly for laboratory research purposes. It is not intended for human consumption, medical use, or unauthorized animal studies. All handling and use should follow applicable laboratory safety and regulatory guidelines.