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Disclaimer: All products are for laboratory research only and not for human or animal use or consumption. For in-vitro research by qualified professionals only

ACE-031

ACE-031

$110.00Price
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Purchase ACE-031 1mg Research Peptide

ACE-031 is a recombinant fusion protein designed for investigational use, targeting the activin type IIB receptor (ActRIIB), an important element within the transforming growth factor-beta (TGF-β) signaling cascade in muscle-related research models. It is engineered by combining the extracellular ligand-binding portion of ActRIIB with the Fc segment of human IgG, forming a soluble decoy receptor for laboratory applications.

Mechanism of Action in Research Settings

In muscle biology studies, myostatin and activin proteins interact with ActRIIB, triggering SMAD2/3 signaling pathways that inhibit muscle cell differentiation. ACE-031 functions by binding these ligands before they reach the receptor, thereby disrupting downstream signaling. Experimental models have shown modulation of gene expression associated with reduced TGF-β activity and increased markers of muscle cell development.

Summary of Scientific Literature

Research published in Nature Medicine (2011) demonstrated that ActRIIB-Fc constructs promoted muscle cell growth in cultured myoblasts and increased muscle mass in animal studies. Additional work in PLOS Biology (2014) examined ligand interactions and signaling pathways, confirming the compound’s specificity and biological effects through biochemical and gene expression analyses.

Product Details – ACE-031 1mg

This product is provided as 1mg of lyophilized recombinant protein. Recommended storage is at -20°C. For laboratory use, it may be reconstituted with sterile phosphate-buffered saline (PBS) or purified research-grade water, yielding an estimated concentration of 0.5–1.0 mg/mL. Purity is ≥95% as determined by SDS-PAGE, with endotoxin levels below 1 EU/mg. Intended for use in cell-based assays and tissue research protocols.

Research Use Notice

This material is strictly for laboratory research purposes. It is not approved for human use, therapeutic applications, or unapproved animal studies. Proper handling should follow established biosafety and recombinant protein research standards.

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