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Disclaimer: All products are for laboratory research only and not for human or animal use or consumption. For in-vitro research by qualified professionals only

MOTS-c

MOTS-c

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Purchase MOTS-c Research Peptide

MOTS-c (Mitochondrial Open Reading Frame of the Twelve S rRNA-c) is a mitochondria-derived peptide extensively studied in metabolic biology, aging research, and exercise physiology for its role as a potent regulator of cellular energy homeostasis and insulin sensitivity. This mitochondrially encoded peptide serves as a critical research tool for investigating metabolic signaling, stress response pathways, and longevity mechanisms in preclinical models.

MOTS-c Identity & Structural Overview

MOTS-c is a 16-amino acid peptide encoded within the mitochondrial 12S ribosomal RNA gene, representing a novel class of mitochondria-derived signaling peptides distinct from nuclear-encoded hormones. Its sequence (Tyr-Arg-Trp-Leu-Leu-Thr-Pro-Glu-Thr-Val-Ala-Ile-Lys-Pro-Cys-Ala) is highly conserved across mammalian species, suggesting fundamental biological relevance in metabolic regulation and cellular stress adaptation across preclinical model systems.

Mechanism of Action

Preclinical research demonstrates that MOTS-c translocates from mitochondria to the nucleus in response to metabolic stress, where it directly regulates nuclear gene expression through interaction with the AMPK pathway and activates the integrated stress response (ISR). Studies have documented its capacity to enhance glucose uptake, suppress de novo lipogenesis, restore insulin sensitivity in insulin-resistant cellular models, and modulate folate and methionine metabolism through the one-carbon cycle in isolated tissue preparations and intact animal models.

Key Research Findings

Foundational research by Lee et al. (2015) published in Cell Metabolism identified MOTS-c as a mitochondria-derived peptide capable of regulating insulin sensitivity and metabolic homeostasis, demonstrating significant reductions in diet-induced obesity and improved glucose tolerance in preclinical animal models. Subsequent work by Kim et al. documented age-dependent decline in circulating MOTS-c concentrations, with exogenous administration shown to restore metabolic function and physical capacity in aged animal preparations, establishing its relevance to aging biology research.

Product Specifications

  • Form: Lyophilized powder (synthetic, high-purity)

  • Sequence: Tyr-Arg-Trp-Leu-Leu-Thr-Pro-Glu-Thr-Val-Ala-Ile-Lys-Pro-Cys-Ala

  • Amino Acid Composition: 16 amino acids

  • Molecular Weight: 2,174.6 Da

  • Quantity: Single-vial format

  • Storage: −20°C; unopened shelf life of 24 months

  • Reconstitution: Sterile water or bacteriostatic saline

  • Purity: >95% (HPLC verified); endotoxin <1 EU/μg

Research Use Only

For preclinical research purposes only. Not intended for human or veterinary use. All handling must adhere to institutional biosafety committee guidelines.

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