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Disclaimer: All products are for laboratory research only and not for human or animal use or consumption. For in-vitro research by qualified professionals only

PT141

PT141

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Purchase PT-141 Research Peptide

PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide and melanocortin receptor agonist extensively studied in neuropharmacology and sexual health research for its role as a centrally acting modulator of sexual arousal pathways. Derived from the tanning peptide Melanotan II, PT-141 serves as a valuable research tool for investigating melanocortin receptor signaling, hypothalamic arousal circuits, and autonomic nervous system regulation in preclinical models.

PT-141 Identity & Structural Overview

PT-141 (cyclo-[Nle⁴-Asp⁵-His⁶-D-Phe⁷-Arg⁸-Trp⁹-Lys¹⁰]-γ-lactam) is a cyclic heptapeptide analog of alpha-melanocyte stimulating hormone (α-MSH). Its cyclic structure confers significantly enhanced metabolic stability and receptor binding affinity compared to its linear parent peptide, making it a reliable ligand for melanocortin receptor studies in biochemical assays and cellular systems. The D-phenylalanine substitution at position 7 is critical for selective MC3R and MC4R receptor engagement.

Mechanism of Action

Preclinical research demonstrates that PT-141 selectively activates melanocortin receptor subtypes MC3R and MC4R within the hypothalamus and limbic system, initiating downstream cAMP-mediated signaling cascades that modulate dopaminergic and oxytocin neurotransmission. Studies have documented its capacity to activate pro-erectile neural pathways, enhance lordosis behavior in female animal models, and modulate autonomic cardiovascular tone independently of peripheral vascular mechanisms, distinguishing its central mechanism from peripherally acting compounds in isolated neural and intact animal preparations.

Key Research Findings

Foundational research by Wessells et al. published in Neuroscience documented PT-141-mediated pro-erectile activity in preclinical animal models through central melanocortin receptor activation, establishing its hypothalamic mechanism of action. Subsequent work by Pfaus et al. demonstrated MC4R-dependent modulation of female sexual behavior in rodent models, while additional preclinical studies have characterized its cardiovascular signaling profile and receptor subtype selectivity in isolated tissue preparations and in vivo pharmacological assays.

Product Specifications

  • Form: Lyophilized powder (synthetic, high-purity)

  • Chemical Name: Bremelanotide; cyclo-[Nle⁴-Asp⁵-His⁶-D-Phe⁷-Arg⁸-Trp⁹-Lys¹⁰]-γ-lactam

  • Molecular Weight: 1,025.2 Da

  • Quantity: Single-vial format

  • Storage: −20°C; unopened shelf life of 24 months

  • Reconstitution: Sterile water or bacteriostatic saline

  • Purity: >95% (HPLC verified); endotoxin <1 EU/μg

Research Use Only

For preclinical research purposes only. Not intended for human or veterinary use. All handling must adhere to institutional biosafety committee guidelines.

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