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Disclaimer: All products are for laboratory research only and not for human or animal use or consumption. For in-vitro research by qualified professionals only

Snap-8

Snap-8

$25.00Price
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Purchase Snap-8 Research Peptide


Snap-8 (Acetyl Octapeptide-3) Research Peptide

Snap-8 is a synthetic octapeptide developed as an extended analog of Argireline (Acetyl Hexapeptide-8), studied in cosmetic biochemistry and dermal research for its effects on neuromuscular signaling at the skin-muscle interface. It's widely used in cosmetic science research investigating SNARE complex inhibition and expression-line formation.

Identity & Structural Overview

Snap-8 (Acetyl Glu-Glu-Met-Gln-Arg-Arg-Asn-Phe-NH₂) is an acetylated octapeptide derived by extending the Argireline hexapeptide sequence with two additional amino acid residues, designed to improve binding affinity to components of the SNARE (soluble NSF attachment protein receptor) complex compared to its shorter precursor.

Mechanism of Action

Research indicates Snap-8 acts by interfering with the assembly of the SNARE complex — specifically implicated in inhibiting interactions among SNAP-25, syntaxin, and VAMP proteins required for vesicle docking and fusion at the presynaptic membrane. By modulating this complex, studies suggest reduced acetylcholine vesicle release at the neuromuscular junction, theoretically decreasing the frequency and intensity of muscle micro-contractions associated with expression-line formation (e.g., forehead and periorbital lines) in in vitro and ex vivo skin models.

Key Research Findings

Comparative studies between Snap-8 and Acetyl Hexapeptide-8 have reported that the extended sequence shows greater inhibitory activity on catecholamine release from chromaffin cells in some assay systems, suggesting stronger interference with the exocytotic machinery. Topical formulation studies have examined penetration characteristics and stability of Snap-8 in various carrier systems for cosmetic research applications.

Product Specifications

  • Form: Lyophilized powder (synthetic, high-purity)

  • Sequence: Acetyl Glu-Glu-Met-Gln-Arg-Arg-Asn-Phe-NH₂

  • Amino Acid Composition: 8 amino acids

  • Molecular Weight: ~1,075.2 Da

  • Quantity: Single-vial format

  • Storage: −20°C; unopened shelf life of 24 months

  • Reconstitution: Sterile or deionized water

  • Purity: >95% (HPLC verified)

Research Use Only — Not intended for human application, ingestion, or injection.

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