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Disclaimer: All products are for laboratory research only and not for human or animal use or consumption. For in-vitro research by qualified professionals only

Thymosin Alpha-1

$39.99Price
Quantity
5mg
10mg
Quantity

Purchase Thymosin Alpha-1 Research Peptide

Thymosin Alpha-1 (Tα1) is a naturally occurring 28-amino acid peptide derived from prothymosin alpha and extensively studied in immunology and infectious disease research for its role as a potent modulator of innate and adaptive immune responses. This thymic peptide serves as a critical research tool for investigating T-cell maturation, dendritic cell activation, and immune surveillance mechanisms in preclinical models.

Thymosin Alpha-1 Identity & Structural Overview

Thymosin Alpha-1 is a 28-amino acid acetylated peptide originally isolated from thymosin fraction 5 of thymic tissue. Its N-terminal acetylation is essential for biological activity, conferring resistance to aminopeptidase degradation and enhancing receptor interaction stability. The peptide sequence (Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn) is highly conserved across mammalian species, reflecting its fundamental role in immune system regulation across preclinical model systems.

Mechanism of Action

Preclinical research demonstrates that Thymosin Alpha-1 exerts its immunomodulatory effects primarily through Toll-like receptor (TLR) signaling pathways, particularly TLR2 and TLR9, driving dendritic cell maturation and augmenting T-helper cell differentiation. Studies have documented its capacity to upregulate major histocompatibility complex (MHC) class II expression, enhance natural killer (NK) cell cytotoxicity, stimulate interferon-gamma and interleukin-2 production, and suppress regulatory T-cell activity in both in vitro cellular preparations and intact animal models.

Key Research Findings

Foundational research by Goldstein et al. originally isolated and characterized Thymosin Alpha-1 from bovine thymic tissue, establishing its role as the primary immunologically active component of thymosin fraction 5. Subsequent work by Romani et al. published in the Journal of Immunology documented Thymosin Alpha-1-mediated dendritic cell activation and Th1 immune polarization in fungal infection models, while additional preclinical studies have demonstrated significant antiviral and antitumor immune enhancement activity in murine model systems.

Product Specifications

  • Form: Lyophilized powder (synthetic, high-purity)

  • Sequence: Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn

  • Amino Acid Composition: 28 amino acids

  • Molecular Weight: 3,108.4 Da

  • Quantity: Single-vial format

  • Storage: −20°C; unopened shelf life of 24 months

  • Reconstitution: Sterile water or bacteriostatic saline

  • Purity: >95% (HPLC verified); endotoxin <1 EU/μg

Research Use Only

For preclinical research purposes only. Not intended for human or veterinary use. All handling must adhere to institutional biosafety committee guidelines.

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